The tumors are often seen on the limbs but may be found on the trunk, as well. The overgrowth of cells is what results in a tumor.įibrosarcomas are seen most often in large-breed, middle-aged to older male dogs. With cancer, the injured or mutated cells begin to multiply at an accelerated rate. Examples of such factors are exposure to chemicals or radiation (carcinogens), infection, hormonal changes, and, more often seen in cats, certain vaccinations. The cause of these tumors is unknown but it is thought that cancer, in general, is the result of many contributing factors that cause genetic injury to cells. Neurofibromas, peripheral nerve sheath tumors, spindle cell tumors, schwannomas, and hemangiopericytomas are all names for fibrosarcoma-type tumors.Ĭause and Presentation of Fibrosarcoma Tumors Therefore, there are several different names in addition to fibrosarcoma that you may hear when this category of tumors is discussed. These tumors are difficult to classify and are often thought of as a group because of the parallel resemblance in their presentation. It is rare that fibrosarcomas metastasize (spread) to other parts of the body. While these tumors may be removed successfully, they frequently recur after surgery. Malignant CSCMTs need to be evaluated by IHC to ensure the histotype and the relatively benign clinical behavior, despite their large size.Ĭanine mammary tumor grading immunophenotype prognosis spindle cell.Fibrosarcomas are slow-growing, malignant (cancerous) tumors most often found in the connective tissue of the skin and beneath the skin. Higher sarcoma grade was associated with older age ( P =. The majority of malignant CSCMTs were solitary (57%) large tumors (6.42 ± 3.92 cm) with low metastatic potential and high survival rate (8% tumor-related mortality). The diagnosis based on the HE-stained section differed from the diagnosis after IHC in 75% of the malignant cases. CSCMTs included 3 benign tumors (1 angioma and 2 benign myoepitheliomas) and 67 malignant tumors that after IHC were diagnosed as malignant myoepithelioma (64%), carcinoma and malignant myoepithelioma (19%), hemangiosarcoma (8%), undifferentiated sarcoma (5%), peripheral nerve sheath tumor (3%), and fibrosarcoma (2%). The prevalence of CSCMT was 1% of all CMTs. The origin of the tumors was assessed as mammary, skin, or unknown. The tumors were diagnosed based on the hematoxylin and eosin (HE)-stained section malignant tumors were graded using a canine soft tissue sarcoma grading scheme and a canine mammary tumor grading scheme, and they were further assigned a diagnosis based on immunohistochemistry (IHC) for pancytokeratin, cytokeratin 14, p63, calponin, vimentin, Ki-67, CD31, desmin, myosin, smooth muscle actin, glial fibrillary acidic protein, and S-100. Mammary tumors submitted for histopathology from 1998 to 2013 and compatible with CSCMTs were retrospectively selected. Canine spindle cell mammary tumor (CSCMT) is an infrequent canine mammary tumor (CMT) composed of spindle or fusiform cells, which represents a challenge for pathologists and clinicians.
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